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Biotage AB launches share buy-back
Resolutions at the Annual General Meeting in Biotage AB on April 25, 2013
Interim report January - March 2013

Biotage and Peptide SynthesisComing soon: Isolera™ Dalton - Flash Chromatography with Integrated Mass IdentificationISOLUTE® Myco SPE columns, a dedicated product for the efficient extraction of mycotoxins from food matricesTLC-to-Step Gradient capability significantly reduces both purification time and solvent useBiotage Releases New Catalog and Technical Guide for Sample Preparation and EvaporationBiotage moving into Mass Directed Flash
 

 

Published Articles
Synthesis 

PDF A Novel Polymer Supported Approach to Nucleoside Modification
Bae, Suyeal; Lakshman, Mahesh K.
JOC Article, December 2007
PDF Microwave synthesis for Everyone (737 kB)
Chemistry in Britain, June 2003 
PDF Microwave synthesis a new wave of synthetic chemistry (1 269kB)
LabPlus International, April/May 2003 
PDF Mikrobolgebaseret kemi - nue muligheter for hurtigere syntese
og metodeudvikling (2 685 kB)

(in Danish) Dansk Kemi, 84, nr. 2, 2003
PDF Microwave synthesis and knowledge management: A productivity revolution (976 kB)
Current Drug Discovery, February 2003 

 

Literature References

Parallel Modification of Tropane Alkaloids
Aberler, N. S.; Ganesan, A.; Lambert, J. N.; Saubern, S.; Smith, R. Tetrahedron Letters, 2001, 42, 1975-1977.
Related products: PS-Trisamine, PS-Triphenylphosphine, MP-Carbonate

A Polymer Bound Iminophosphorane Approach for the Synthesis of Quinazolines
Zhang, W.; Mayer, J.P.; Hall, S. E.; Weigel, J. A. J. Comb. Chem. 2001, 3, 255-256
Related product: PS-Triphenylphosphine

Mitsunobu Reaction Modifications Allowing Product Isolation Without Chromatography: Application to a Small Parallel Library
Pelletier, J.C.; Kincaid, S. Tetrahedron Letters, 2000, 41, 797-800.
Related product: PS-Triphenylphosphine

Michael Reactions in Water Using Amphiphilic Resin-Supported Quaternary Ammonium Hydroxides
Shibatomi, K.; Nakahashi, T.; Uozumi, Y. Synlett, 2000, 11, 1643-1645.
Related product: ArgoGel

Mitsunobu Reaction Modifications allowing Product Isolation Without Chromatography: Application to a Small Parallel Library
Pelletier, J. C.; Kincaid, S.; Tetrahedron Letters, 2000, 41, 797-800.
Related product: PS-Triphenylphosphine

Macrolactonization of Hydroxy Acids Using a Polymer Bound Carbodiimide
Keck, G. E.; Sanchez, C.; Wager, A. Tetrahedron Letters, 2000, 41, 8673-8676.
Related product: PS-Carbodiimide

Parallel Solution Phase Synthesis of N-substituted 2-pyrazoline Libraries
Bauer, U.; Egner, B. J.; Nilsson, I.; Berghult, M.; Tetrahedron Letters , 2000, 41, 2713-2717.
Related Products: PS-DIEA,PS-Trisamine,PS-Isocyanate

Alternative Base Matrices for Solid Phase Quenching Reagents
Nicewonger, R. B.; Ditto, L.; Varady, L.; Tetrahedron Letters, 2000, 41, 2323-2326.
Related product: MP-Trisamine

Oxazoline Synthesis from Hydroxamides by Resin Capture and Ring-Forming Release
Pirrung, M. C.; Tumey, N. L.; J. Comb. Chem. 2000, 2, 675-680.
Related product: PS-TsCl

Facile Solid-Phase Construction of Indole Derivatives Based on a Traceless, Activating Sulfonyl Linker
Zhang, H. C.; Ye, H.; Moretto, A. F.; Brumfield, K.; Maryanoff, B. E.; Organic Letters, 2000, 2, 89-92.
Related product: PS-TsCl

Multistep Solution Phase Parallel Synthesis of Spiperone Analogues
Hansen, H.C.; Olsson, R.; Croston, G.; Anderson, C. M.; Bioorganic and Medicinal Chemistry Letters, 2000, 10, 2435-2439.
Related product: PS-TsCl

Use of Polymer Supported Thiophenol for the Synthesis and Purification of a Benzimidazol-2-one Library
Ermann, M.;Simkovsky, N.M.; Roberts, S. M.; parry, D. M.; Baxter, A. D.; Montana, J.G. Tetrahedron Letters, 2000, 41, 2483-2485.
Related product: PS-Thiophenol

A Convenient and Scalable Procedure for Removing the Fmoc Group in Solution
Sheppeck, J. E.; Kar, H.; Hong, H. Tetrahedron Letters, 2000, 41, 5329-5333.
Related product: PS-Thiophenol

Use of Polymer Supported Thiophenol for the Synthesis and Purification of a Benzimidazol-2-one Library
Ermann M., Simkovsky N.M., Roberts S.M., Parry D.M., Baxter A.D. and Montana J.G, Tetrahedron Letters 41, 2483–2485
Related product: PS-Thiophenol

Synthesis of Enamides Related to the Salicylate Antitumor Macrolides Using Coper-Mediated Vinylic Substitution
Shen R., Porco J.A., Organic Letters, 2000, 2, 9, 1333-1336.
Related product: Quest 210

Polymer-Supported Silyl Cyanide and Silyl Azide: Useful Reagents for Solid-Phase Applications
Missio A., Marchioro C., Rossi T., Panunzio M., Selva S., Seneci P. (GlaxoWellcome Medicines Research Centre, Verona (Italy)) Biotechnology and Bioengineering, 2000, 71, 1, 38-43.
Related product: PS-DES

Kinetic Comparison of Trifluroroacetic Acid Cleavage Reactions of Resin-Bound Carbamates, Ureas, Secondary Amides, and Sulfonamides from Benzyl-, Benzhydryl- and Indole-Based Linkers
Yan, B; Nguyen, N; Liu, L.; Holland, G. Raju, B. J.Comb. Chem. 2000, 2, 66-74.
Related product: PS-Indole-CHO, PS-MB-CHO 

Synthesis of Highly Substituted 5-(Trifluoromethyl)ketoimadazoles Using a Mixed-Solid/Solution Phase Motif
Hamper, B.; Jerome, K.D.; Yalamanchili, G.; Walker, D.M.; Chott, R.C. Mischke, D.A. Biotechnology and Bioengineering (Combinatorial Chemistry), 2000, 71, 1, 28-37.

Polymer-Supported Silyl Cyanide and Silyl Azide: Useful Reagents for Solid-Phase Applications
Missio, A.; Marchioro, C.; Rossi, T; Panunzio, M.; Selva, S.; Seneci, P. Biotechnology and Bioengineering (Combinatorial Chemistry), 2000, 71, 1, 38-43.
Related product: PS-DES

Polymer-Assisted Solution-Phase (PASP) Library Synthesis of a -Ketoamides
South, M.S.; Dice, T.A.; Parlow, J.J. Biotechnology and Bioengineering (Combinatorial Chemistry), 2000, 71, 1, 51-57.
Related product: PS-Carbodiimide, PS-Trisamine


The following papers are among recent publication references that report successful use of resin-bound reagents and scavengers in microwave-assisted synthesis.

 Increasing Rates of Reaction: Microwave assisted Organic Synthesis for Combinatorial Chemistry
Lew, A; Krutzik, P.O.; Hart, M.E.; Chamberlain, A. R.; J. Combi. Chem. 2002, 4, 95-105.

Synthesis of 1,3,4-Oxadiazoles Using Polymer-Supported Reagents
Brain, C.T.;Synlett 2001, 382-384.

An Efficient Combination of Microwave Dielectric Heating and the use of Solid-Supported Triphenylphosphine for Wittig Reactionse
Westman, J.; Org. Lett. 2001, 3(23), 3745-3747.

A Polymer Supported Thionating Reagent
Ley, S.V.; Leach, A.G.; Storer, R.I.; J. Chem. Soc. Perkin Trans 2001, 4, 358-361.

Thermal and Microwave Assisted Hydrogenation of Electron-deficient Alkenes Using a Polymer-Supported Hydrogen Donor
Desai, B.; Danks, T. N.; Tetrahedron Letters, 2001, 42, 5963-5965.

A Polymer-Supported [1,3,2] Oxazaphospholidine for the Conversion of Isothiocyanates to Isocyanides and Their Subsequent Use in an Ugi Reaction
Ley, S. V.; Taylor, S.J.; Bioorg. Med. Chem. Lett. 2002, 12, 1813-1816.

Fast Microwave-assisted Preparation of Aryl and Vinyl Nitriles and the corresponding Tetrazoles from Organo-halides
Alterman, M.; Hallberg, A.; J. Org. Chem. 2000, 65, 7984-7989.

Rapid Parallel Synthesis Utilizing Microwave Irradiation
8. Glass, B.; Combs, A.P.; In High-Throughput Synthesis. Principles and Practices; Sucholeiki, I., Ed.; Marcel Dekker:New York, 2001, pp 123-128.

High-Throughput Synthesis of N3-Acylated Dihydropyrimidines Combining Microwave-Assisted Synthesis and Scavenging Techniques
Dallinger, D.; Gorobets, N. Y.; Kappe, C. O.; Org. Lett, 2003, 5, 1205-1208.

 

 


 
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